Jann Sarkaria

Company: Mayo Clinic

Job title: Professor of Radiation Oncology

Seminars:

Integration of PDX Modeling & Pharmacokinetics to Inform Clinical Development of the Novel ATM inhibitor WSD0628 11:30 am

Use of in vitro and PDX modeling to define target drug concentrations for a novel ATM inhibitor WSD0628 Integration of Kp and Kpuu to define target human plasma concentrations for robust radiosensitization in GBM Analysis of human PK data to inform further dose-escalation in the first-inhuman clinical trial of WSD0628 and radiation in recurrent GBM…Read more

day: Day Two

Fireside Chat: How Can We Holistically Prioritise Combination Strategies Across the DDR Landscape & Leverage These to Tackle PARP inhibitor resistance? 11:30 am

How can we effectively integrate combination strategies that target complementary DNA damage response (DDR) pathways, such as combining PARP inhibitors with emerging DDR modulators like USP1 inhibitors, to enhance therapeutic efficacy? What role do biomarkers, particularly those related to homologous recombination repair (HRR) deficiencies, play in guiding the selection of optimal combination therapies tailored to…Read more

day: Day One