Optimizing Dosage Strategies for DDR Inhibitors Integrating Preclinical & Clinical Knowledge Using Model Informed Drug Development
Time: 8:00 am
day: Day One
Details:
- Addressing tolerability challenges by optimizing dosage strategies for DDR inhibitors using PK/PD framework, ensuring multicycle tolerability within the expected therapeutic range
- Integrating available preclinical and clinical knowledge using MIDD framework to inform dosage decisions in early phase combination treatment development
- Utilizing predictive modeling to anticipate potential adverse effects and adjust combination therapy regimens for enhanced safety and efficacy in patients
