Fireside Chat: How Can We Holistically Prioritise Combination Strategies Across the DDR Landscape & Leverage These to Tackle PARP inhibitor resistance?
Time: 11:30 am
day: Day One
Details:
- How can we effectively integrate combination strategies that target complementary DNA damage response (DDR) pathways, such as combining PARP inhibitors with emerging DDR modulators like USP1 inhibitors, to enhance therapeutic efficacy?
- What role do biomarkers, particularly those related to homologous recombination repair (HRR) deficiencies, play in guiding the selection of optimal combination therapies tailored to specific genetic contexts?
- How should we address the safety implications and potential resistance mechanisms of DDR combination therapies to ensure balanced strategies that maximize efficacy while minimizing toxicity and long-term resistance?
