Exploring Oncogenic Stress & DNA Repair Defect as Biomarkers for DDR Therapies
Time: 9:00 am
day: Pre-Conference Biomarker Focus Day AM
Details:
- Understanding how both replication stress caused by oncogenic mutations and DNA repair mutations increase reliance on cell cycle checkpoint regulators and DNA repair proteins to maintain genome integrity
- Assessing how inhibition of these cell cycle checkpoints and DNA repair proteins in the context of such cancer-associated mutations leads to more selective genome destabilization and killing of cancer cells compared to normal, unmutated cells
- Identifying the cancer-associated mutations that cause sensitivity to these inhibitors and how they can enhance the therapeutic potential of these drugs and decrease toxicity to normal tissues
