Exploring Next-Gen PARP Inhibitors without PARP Trapping
Time: 3:45 pm
day: Day Two
Details:
- Evaluating next-gen PARP inhibitors that selectively target PARP1 without trapping, aiming to minimize hematological toxicity and enhance safety in combination with DNA-damaging agents
- Focusing on improving blood-brain barrier penetration to address the unmet needs in treating brain metastases and glioblastomas
- Exploring the potential of these next-gen PARP inhibitors in combination with various DNA-damaging therapies to broaden their therapeutic applications