Balancing Efficacy and Safety Through Biomarker-Guided Dosing

• How can predictive and pharmacodynamic biomarkers be integrated to define the therapeutic

window?

• What are the key challenges in translating preclinical biomarker data into dosing strategies in patients?

Ensuring Sample Quality & Standardization to Strengthen Translational DDR Research

• What standardized approaches to sample collection and processing are essential to ensure reliable biomarker readouts?

• How can improved sample quality accelerate translation from patient samples to preclinical models and clinical trial design?

Designing & Deploying Combination Biomarkers to Guide DDR Combination Therapies

• How can combination biomarkers be structured to both increase prediction accuracy while maintaining the rate of patient eligibility?

• What practical approaches make composite biomarker panels feasible in clinical trials while meeting regulatory expectations?