Anang Shelat

Anang Shelat

Company: St. Jude Children’s Research Hospital

Job title: Professor & Director - Compound Management & Discovery Informatics Lead


ATM Inhibition Enhances the Efficacy of Radiation Across Distinct Molecular Subgroups of Pediatric High-Grade Glioma 4:00 pm

AZD1390 potentiated radiation across distinct molecular subgroups of pediatric high grade glioma cell lines ATM inhibition improved the efficacy of radiation in both TP53 wild-type and TP53 mutant orthotopic xenograft models We identified a novel mechanism of resistance to ATMi + radiation marked by an attenuated ATM pathway response and synthetic lethality with ATR inhibitionRead more

day: Day Two

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