A Transcriptomic Model of Homologous Recombination Deficiency in a Real-World Pan-Cancer Cohort

Time: 3:30 pm
day: Day One


  • Gene expression can be used to accurately predict HRD-status across solid tumor cohorts
  • This transcriptomic model, HRD-RNA, enriches for samples with biallelic loss in BRCA1/2 and other genes in the homologous recombination pathway
  • Cohorts, outside traditional BRCA-associated cohorts, have samples with biallelic loss of BRCA1/2 and samples predicted HRD+, suggesting new avenues for HRD targeted therapies