Progress in PKMYT1 Inhibition: RP-6306

Time: 2:30 pm
day: Day Two


• PKMYT1 is synthetic lethal with CCNE1 amplification and FBXW7 deleterious mutation and represents a unique targeting opportunity in patients with significant unmet need
• RP-6306 is a potent and selective inhibitor of PKMYT1 that is safe and efficacious in models of CCNE1 amplification and FBXW7 loss
• Combination of RP-6306 with standard of care chemotherapy results in rapid and profound regression in xenograft models at very well tolerated doses and schedules