Exploring the Landscape of PARP Inhibitor Selectivity in Cells with NanoBRET

Time: 2:50 pm
day: Day One

Details:

• Introduction to NanoBRET Target Engagement: WEE1, PKMYT1, and CHK1 kinase inhibitor profiling in cells
• Development of a pan-PARP live cell target engagement system
• Revealing unexpected engagement of understudied mono-PARPs in cells