Closing Panel Discussion: Future Directions for DDRi

Time: 5:30 pm
day: Day Two


  • What is the current status of DDRi combination with IO
  • Thoughts and rationalizing on potential best outcomes DDR-DDR combos
  • Reviewing the various combination approaches and new targets coming in – thought experiment based on pathway
  • What are the combinations and new targets that are going to push the field forward in a durable and effective way?
  • Designing for approval in monotherapy vs comb therapy?
  • PARP combination directions
  • How far to take monotherapies?
  • How can we be equally successful with PARP in other cancer types?
  • What makes DDRis so powerful?
  • Advice on how to take novel targets into the clinic?
  • Where is this field going?