ATM Inhibition Enhances the Efficacy of Radiation Across Distinct Molecular Subgroups of Pediatric High-Grade Glioma

Time: 4:00 pm
day: Day Two


  • AZD1390 potentiated radiation across distinct molecular subgroups of pediatric high grade glioma cell lines
  • ATM inhibition improved the efficacy of radiation in both TP53 wild-type and TP53 mutant orthotopic xenograft models
  • We identified a novel mechanism of resistance to ATMi + radiation marked by an attenuated ATM pathway response and synthetic lethality with ATR inhibition